反应详情

温度

100 °C

To a stirred solution of 6-bromo-8-fluoro-3,4-dihydroquinolin-2(1H)-one (109-3; 8 g, 0.032 mol) in toluene (30 mL) was added Lawesson's reagent (13.26 g, 0.032 mol). Reaction mass was refluxed at 100° C. for 12 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound. MS (M+1): 262.0.

1. customReaction mass
2. concentrationThe reaction mixture was concentrated
3. customdirectly purified by silica gel column chromatography