HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1521630Generated: October 30, 2026
Lawesson's reagent → 6-bromo-8-fluoro-3,4-dihydroquinoline-2(1H)-thione
https://huagongshe.com/reaction/1521630
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 6-BROMO-8-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE | HCID 70977460 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6-bromo-8-fluoro-3,4-dihydroquinoline-2(1H)-thione | HCID 89156071 | — |
Reaction Steps
To a stirred solution of 6-bromo-8-fluoro-3,4-dihydroquinolin-2(1H)-one (109-3; 8 g, 0.032 mol) in toluene (30 mL) was added Lawesson's reagent (13.26 g, 0.032 mol). Reaction mass was refluxed at 100° C. for 12 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound. MS (M+1): 262.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09073929B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-e3c44ff3e03844d5bf330e1e3a6800c5 |
|---|
| Source note | uspto-grants-2015_07 |
|---|
