反应详情

温度

100 °C

To a stirred solution of 6-bromo-5-cyclopropyl-3,4-dihydroquinolin-2(1H)-one (147-6; 0.8 g, 0.0030 mol) in toluene (10 mL) was added Lawesson's reagent (1.2 g, 0.003 mol). Reaction mass was refluxed at 100° C. for 12 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound. MS (M+1): 284.0.

1. customReaction mass
2. concentrationThe reaction mixture was concentrated
3. customdirectly purified by silica gel column chromatography