Lawesson's reagent → 6-bromo-5-cyclopropyl-3,4-dihydroquinoline-2(1H)-thione

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 6-bromo-5-cyclopropyl-3,4-dihydroquinolin-2(1H)-one (147-6; 0.8 g, 0.0030 mol) in toluene (10 mL) was added Lawesson's reagent (1.2 g, 0.003 mol). Reaction mass was refluxed at 100° C. for 12 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound. MS (M+1): 284.0.

Provenance & Evidence