反应详情

To a solution of 3-[2-(tetrahydro-4H-pyran-4-ylidene)hydrazinyl]propanenitrile (5 g, 30 mmol) in 1-propanol (50 mL) is added NaOH (29 mg, 0.74 mmol) and reaction mixture is heated at reflux for 16 h. The solvent is evaporated under reduced pressure and the residue is filtered through neutral alumina eluting with ethyl acetate to afford the title compound as a yellow solid (1.6 g, 32%) which is used in the next step without purification.

1. temperatureis heated
2. temperatureat reflux for 16 h
3. customThe solvent is evaporated under reduced pressure
4. filtrationthe residue is filtered through neutral alumina eluting with ethyl acetate