Potassium Carbonate → HCID 86682398, compound

HRID 1521739Notes

Reaction equation

HRID 1521739 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:3]=1.[N+:22]([O-])([O-:24])=[O:23].[K+].C([O-])([O-])=O.[K+].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[C:6]([N+:22]([O-:24])=[O:23])[C:5]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:11])[F:12])=[C:4]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 24434Potassium NitrateHCID 86682397HCID 86682397, compound

Product 1

HCID 86682398HCID 86682398, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of N-[4-chloro-2-(morpholin-4-ylmethyl)phenyl]-2,2,2-trifluoroacetamide (3.8 g, 11.8 mmol) in concentrated sulfuric acid (35 mL) cooled to 0° C. is added potassium nitrate (1.4 g, 14.1 mmol). The reaction is slowly warmed to room temperature over a period of 2 h and then poured into ice H2O. The mixture is neutralized with saturated aqueous K2CO3 and the resulting solid is collected by filtration to afford the title compound (3.6 g, 82%).

Workup

  1. filtrationthe resulting solid is collected by filtration

Sources & evidence

ORD record
ord-308c271bf88f4109a2d35c3d80fab59c
Source dataset
uspto-grants-2015_07
Patent number
US09073926B2

Reaction notes

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