Sodium Hydroxide → HCID 67235137, compound

HRID 1521740Notes

Reaction equation

HRID 1521740 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([NH:11]C(=O)C(F)(F)F)=[C:4]([CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([NH2:11])=[C:4]([CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86682398HCID 86682398, compound

Product 1

HCID 67235137HCID 67235137, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of N-[4-chloro-2-(morpholin-4-ylmethyl)-6-nitrophenyl]-2,2,2-trifluoroacetamide (3.6 g, 9.6 mmol) in ethanol (60 mL) is added a 10% aqueous NaOH solution (60 mL, 150 mmol). The reaction is heated to 80° C. for 3 hours and then left at room temperature overnight. Most of the ethanol is removed under reduced pressure and the resulting solid is isolated by filtration to afford the title compound (2 g, 77%).

Workup

  1. customMost of the ethanol is removed under reduced pressure
  2. customthe resulting solid is isolated by filtration

Sources & evidence

ORD record
ord-4ab132b0f2284b30acccb59b966c09f8
Source dataset
uspto-grants-2015_07
Patent number
US09073926B2

Reaction notes

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