Sodium Hydroxide → HCID 67235137, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[4-chloro-2-(morpholin-4-ylmethyl)-6-nitrophenyl]-2,2,2-trifluoroacetamide (3.6 g, 9.6 mmol) in ethanol (60 mL) is added a 10% aqueous NaOH solution (60 mL, 150 mmol). The reaction is heated to 80° C. for 3 hours and then left at room temperature overnight. Most of the ethanol is removed under reduced pressure and the resulting solid is isolated by filtration to afford the title compound (2 g, 77%).

Provenance & Evidence