HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-3-methylisoxazole → 4-(6-Fluoro-1H-indazol-5-yl)-3,6-dimethyl-4,7-dihydroisoxazolo[5,4-b]pyridine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-3-methylisoxazole | HCID 84590 | — |
| Reactant | (2E)-2-[(6-fluoro-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile | HCID 66616240 | — |
| Product | 4-(6-Fluoro-1H-indazol-5-yl)-3,6-dimethyl-4,7-dihydroisoxazolo[5,4-b]pyridine-5-carbonitrile | HCID 135985998 | — |
Reaction Steps
100 mg (0.44 mmol) (2E)-2-[(6-fluoro-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile (Example 13A) were treated with 3-methyl-1,2-oxazol-5-amine following the procedure described in Example 2. The crude material was purified by preparative RP-HPLC (methanol/water+0.1% TFA gradient) to yield 55 mg (41% of th.) of the racemic title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073939B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-0d047b3a98d946f6b3e51ac472b9a281 |
| Source note | uspto-grants-2015_07 |