HRID1521802

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1C(=O)O

HCID18396216

2-(1,1-Dimethylethyl) (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate

C12H19NO4

结构：O=C(CBr)c1ccc2c(ccc3cc(C(=O)CBr)sc32)c1

HCID89751851

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H](C2)[C@H]1C(=O)OCC(=O)c1ccc2c(ccc3cc(C(=O)COC(=O)[C@@H]4[C@H]5CC[C@H](C5)N4C(=O)OC(C)(C)C)sc32)c1

HCID117778314

未命名化合物

PROCEDURE

实验过程

was synthesized from 1,1′-(naphtho[1,2-b]thiophene-2,7-diyl)bis(2-bromoethanone) (10c) and (1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (see, e.g., WO 2012/041227) by following an analogous procedure described in Step 5, Example 1. m/z 746.3 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e34d5a9f01d9474d977ae7938a127f99
来源数据集: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09073942B2
来源说明: uspto-grants-2015_07

反应 SMILES

[S:1]1[C:5]([C:6](=[O:9])[CH2:7]Br)=[CH:4][C:3]2[CH:10]=[CH:11][C:12]3[C:17]([C:2]1=2)=[CH:16][CH:15]=[C:14]([C:18](=[O:21])[CH2:19]Br)[CH:13]=3.[C:22]([O:26][C:27]([N:29]1[C@H:34]([C:35]([OH:37])=[O:36])[C@@H:33]2[CH2:38][C@H:30]1[CH2:31][CH2:32]2)=[O:28])([CH3:25])([CH3:24])[CH3:23]>>[C@H:30]12[CH2:38][C@H:33]([CH2:32][CH2:31]1)[C@@H:34]([C:35]([O:37][CH2:19][C:18]([C:14]1[CH:13]=[C:12]3[C:17](=[CH:16][CH:15]=1)[C:2]1[S:1][C:5]([C:6](=[O:9])[CH2:7][O:37][C:35]([C@@H:34]4[C@@H:33]5[CH2:38][C@@H:30]([CH2:31][CH2:32]5)[N:29]4[C:27]([O:26][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:28])=[O:36])=[CH:4][C:3]=1[CH:10]=[CH:11]3)=[O:21])=[O:36])[N:29]2[C:27]([O:26][C:22]([CH3:25])([CH3:23])[CH3:24])=[O:28]