HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo(2.2.1)heptane-3-carboxylic acid → (1R,3S,4S)-3-(2-(2-(2-(((1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carbonyl)oxy)acetyl)naphtho[1,2-b]thiophen-7-yl)-2-oxoethyl) 2-tert-butyl 2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo(2.2.1)heptane-3-carboxylic acid | HCID 18396216 | — |
| Reactant | 1,1'-(Naphtho[1,2-b]thiophene-2,7-diyl)bis(2-bromoethanone) | HCID 89751851 | — |
| Product | (1R,3S,4S)-3-(2-(2-(2-(((1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carbonyl)oxy)acetyl)naphtho[1,2-b]thiophen-7-yl)-2-oxoethyl) 2-tert-butyl 2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate | HCID 117778314 | — |
Reaction Steps
was synthesized from 1,1′-(naphtho[1,2-b]thiophene-2,7-diyl)bis(2-bromoethanone) (10c) and (1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (see, e.g., WO 2012/041227) by following an analogous procedure described in Step 5, Example 1. m/z 746.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073942B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-e34d5a9f01d9474d977ae7938a127f99 |
| Source note | uspto-grants-2015_07 |