Water → HCID 90413495, compound

HRID 1521963Notes

Reaction equation

HRID 1521963 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:41][CH3:42])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[N:14](S(C4C=CC(C)=CC=4)(=O)=O)[C:15]([C:17]4([OH:30])[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH2:18]4)=[CH:16][C:9]=23)[CH:7]=1.[OH-].[Na+].O>O1CCOCC1.C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:41][CH3:42])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[NH:14][C:15]([C:17]4([OH:30])[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:28])([CH3:29])[CH3:27])=[O:24])[CH2:19][CH2:18]4)=[CH:16][C:9]=23)[CH:7]=1

Participants

6

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 90412541HCID 90412541, compound

Product 1

HCID 90413495HCID 90413495, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

A suspension of Example 126B (0.144 g, 0.241 mmol) and 50% sodium hydroxide (0.064 mL, 1.205 mmol)/water (0.064 mL) in dioxane (1 mL) was heated at 80° C. for 4 hours. The mixture was diluted with ethyl acetate and dried over magnesium sulfate, filtered and concentrated. The crude mixture was used in the next step without further purification. LCMS: 442.2 (M+H)+.

Workup

  1. dry with materialdried over magnesium sulfate
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe crude mixture was used in the next step without further purification

Sources & evidence

ORD record
ord-e978965518fc4ab2bd870927bd826424
Source dataset
uspto-grants-2015_07
Patent number
US09073922B2

Reaction notes

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