Sodium Hydroxide → HCID 90412644, compound

HRID 1522045Notes

Reaction equation

HRID 1522045 reaction equation
[F:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[N:14](S(C4C=CC=CC=4)(=O)=O)[C:15]([C:17]4[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]=4)=[CH:16][C:9]=23)[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCOCC1.O>[F:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[NH:14][C:15]([C:17]4[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]=4)=[CH:16][C:9]=23)[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 90412435HCID 90412435, compound

Product 1

HCID 90412644HCID 90412644, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of Example 309D (3.0 g, 5.61 mmol) in 1,4-dioxane (50 mL) was treated with a solution of sodium hydroxide (0.673 g, 16.83 mmol) in water (10 mL). The resulting mixture was stirred at 80° C. overnight. Most solvent was evaporated. The solids were filtered, washed with water/ethyl acetate/ether, and vacuum oven-dried to give the title compound. MS (ESI+) m/z 395.1 (M+H)+.

Workup

  1. customMost solvent was evaporated
  2. filtrationThe solids were filtered
  3. washwashed with water/ethyl acetate/ether, and vacuum
  4. customoven-dried

Sources & evidence

ORD record
ord-b72e11bdc9684e6bb0d7e98d6426d63a
Source dataset
uspto-grants-2015_07
Patent number
US09073922B2

Reaction notes

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