Hydrochloric Acid → 1415824-88-2

HRID 1522089Notes

Reaction equation

HRID 1522089 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[C:3]=1[C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:25][CH:24]=1.Cl>CO>[O:29]([C:26]1[CH:27]=[CH:28][C:23]([C:3]2[C:4]([NH:8][CH2:9][CH:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)=[N:5][CH:6]=[N:7][C:2]=2[NH2:1])=[CH:24][CH:25]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71092747HCID 71092747, compound

Product 1

HCID 710928091415824-88-2

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into a 20-mL vial was placed tert-butyl 4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidine-1-carboxylate (534.60 mg; 1.12 mmol) dissolved in methanol (4.00 ml). Hydrogen chloride (2.0 M solution in diethyl ether) (5.62 ml) was added to the mixture. The reaction was stirred at rt overnight. The reaction mixture was concentrated under reduced pressured and subsequently lyophilized overnight to afford 5-(4-phenoxyphenyl)-N-(piperidin-4-ylmethyl)pyrimidine-4,6-diamine as a yellow solid crude.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressured and subsequently lyophilized overnight

Sources & evidence

ORD record
ord-1d5ec52e9f69434c8e940b3ecc3d3393
Source dataset
uspto-grants-2015_07
Patent number
US09073947B2

Reaction notes

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