Diisopropylethylamine → Tert-butyl 6-((6-amino-5-chloropyrimidin-4-yl)amino)-2-azaspiro[3.3]heptane-2-carboxylate

https://huagongshe.com/reaction/1522094

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	5,6-Dichloro-pyrimidin-4-ylamine	HCID 24219262	—
반응물	tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate	HCID 46930560	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	Tert-butyl 6-((6-amino-5-chloropyrimidin-4-yl)amino)-2-azaspiro[3.3]heptane-2-carboxylate	HCID 71113288	—

반응 조건

온도	155 °C

반응 단계

In a round bottom flask containing 5,6-dichloro-pyrimidin-4-ylamine (300.00 mg; 1.83 mmol; 1.00 eq.) and 6-amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester (466.02 mg; 2.20 mmol; 1.20 eq.) in NMP (1.00 ml) was added DIPEA (0.91 ml; 5.49 mmol; 3.00 eq.). The reaction mixture was stirred at 155° C. for 4 h before it was concentrated.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09073947B2
출처 데이터셋	uspto-grants-2015_07
ORD ID	ord-833bc2d74b0c4306aec7ccbb3b9f9b39
출처 메모	uspto-grants-2015_07