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HRID1522160

反应详情

EQUATION

反应方程式

HRID 1522160 的结构方程式

REACTANTS

反应物

4
结构：C#CC(=O)O
HCID10110

2-Propynoic acid

C3H2O2

结构：OB(O)c1ccc(Oc2ccccc2)cc1
HCID2734377

4-Phenoxyphenylboronic acid

C12H11BO3

结构：Nc1ncnc(Cl)c1Cl
HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

结构：CC(C)(C)OC(=O)N1C2CCC1CC(CN)C2
HCID53487663

未命名化合物

PRODUCTS

生成物

1
结构：C#CC(=O)N1C2CCC1CC(CNc1ncnc(N)c1-c1ccc(Oc3ccccc3)cc1)C2
HCID86721768

未命名化合物

PROCEDURE

实验过程

1-(3-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-8-azabicyclo[3.2.1]octan-8-yl)prop-2-yn-1-one was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate, (4-phenoxyphenyl)boronic acid, and propiolic acid using methods B, C, D, and E. HPLC purity: 96%. MS: m/z=454 [M+H]+.