HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propiolic Acid → HCID 86721768, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propiolic Acid | HCID 10110 | — |
| Reactant | 4-Phenoxyphenylboronic acid | HCID 2734377 | — |
| Reactant | 5,6-Dichloro-pyrimidin-4-ylamine | HCID 24219262 | — |
| Reactant | Tert-butyl 3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate | HCID 53487663 | — |
| Product | HCID 86721768 | HCID 86721768 | — |
Reaction Steps
1-(3-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-8-azabicyclo[3.2.1]octan-8-yl)prop-2-yn-1-one was prepared from 5,6-dichloropyrimidin-4-amine, tert-butyl 3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate, (4-phenoxyphenyl)boronic acid, and propiolic acid using methods B, C, D, and E. HPLC purity: 96%. MS: m/z=454 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073947B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-a65883d7cee3426abd9aad9d3bc819b8 |
| Source note | uspto-grants-2015_07 |