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HRID1522190

反应详情

EQUATION

反应方程式

HRID 1522190 的结构方程式

REACTANTS

反应物

3
反应SMILES：OB(O)c1ccc(Oc2ccccc2)cc1
HCID2734377

4-Phenoxyphenylboronic acid

C12H11BO3

反应SMILES：CC(C)(C)OC(=O)N1CC[C@@H](CN)[C@H](O)C1
HCID11075229

未命名化合物

反应SMILES：Nc1ncnc(Cl)c1Cl
HCID24219262

5,6-Dichloropyrimidin-4-amine

C4H3Cl2N3

PRODUCTS

产物

1
反应SMILES：Cl.Nc1ncnc(NC[C@@H]2CCNC[C@H]2O)c1-c1ccc(Oc2ccccc2)cc1
HCID71092775

未命名化合物

PROCEDURE

实验过程

(3S,4S)-4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-3-ol hydrochloride was prepared from 5,6-dichloropyrimidin-4-amine, (3S,4S)-tert-butyl 4-(aminomethyl)-3-hydroxypiperidine-1-carboxylate, and (4-phenoxyphenyl)boronic acid according to general scheme 3 using methods S1, S2, and S3.