HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-4-(3,3-difluoropiperidin-1-yl)but-2-enoic acid → (E)-N-(3-(4-amino-6-(4-phenoxyphenoxy)pyrimidin-5-yl)phenyl)-4-(3,3-difluoropiperidin-1-yl)but-2-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-4-(3,3-difluoropiperidin-1-yl)but-2-enoic acid | HCID 71093040 | — |
| Reactant | 5-(3-Aminophenyl)-6-(4-phenoxyphenoxy)pyrimidin-4-amine | HCID 71474012 | — |
| Product | (E)-N-(3-(4-amino-6-(4-phenoxyphenoxy)pyrimidin-5-yl)phenyl)-4-(3,3-difluoropiperidin-1-yl)but-2-enamide | HCID 71092856 | 48% |
Reaction Steps
(E)-N-(3-(4-amino-6-(4-phenoxyphenoxy)pyrimidin-5-yl)phenyl)-4-(3,3-difluoropiperidin-1-yl)but-2-enamide was prepared from 5-(3-aminophenyl)-6-(4-phenoxyphenoxy)pyrimidin-4-amine and (E)-4-(3,3-difluoropiperidin-1-yl)but-2-enoic acid using Method E (48% yield). HPLC: 97%, RT=3.809 min. MS: m/z=558 [M+H]+, RT=1.92 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073947B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-1cd02a2941934df0a89703cd103b58ff |
| Source note | uspto-grants-2015_07 |