Sodium Bicarbonate → HCID 56597156, compound

HRID 1522414Notes

Reaction equation

HRID 1522414 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:14]([NH:16][CH2:17][C:18]2[C:19](=[O:26])[NH:20][C:21]([CH3:25])=[CH:22][C:23]=2[CH3:24])=[O:15])[C:5]2[CH:10]=[N:9][N:8]([CH:11]([CH3:13])[CH3:12])[C:6]=2[N:7]=1.[NH2:27][C:28]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)=[O:29].COCCOC.O.C(=O)(O)[O-].[Na+]>C(Cl)Cl.CO.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[NH2:27][C:28]([C:30]1[CH:35]=[CH:34][C:33]([C:2]2[CH:3]=[C:4]([C:14]([NH:16][CH2:17][C:18]3[C:19](=[O:26])[NH:20][C:21]([CH3:25])=[CH:22][C:23]=3[CH3:24])=[O:15])[C:5]3[CH:10]=[N:9][N:8]([CH:11]([CH3:13])[CH3:12])[C:6]=3[N:7]=2)=[CH:32][CH:31]=1)=[O:29]

Participants

7

Reactant 4

HCID 516892Sodium BicarbonateHCID 27378114-Aminocarbonylphenylboronic acidHCID 18180031Water 1,2-dimethoxyethaneHCID 565974256-Chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Product 1

HCID 56597156HCID 56597156, compound

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in the same manner as described in example 93 using 6-chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide (80 mg, 0.21 mmol), [4-(aminocarbonyl)phenyl]boronic acid (52.9 mg, 0.31 mmol), bis(triphenylphosphine)palladium(II) chloride (8.7 mg, 0.01 mmol), DME/water (4 mL, 3:1) and sodium bicarbonate (54 mg, 0.62 mmol). The crude product was dissolved in DCM/MeOH (1:1) and preabsorbed onto silica gel. The product was purified by silica gel chromatography (eluent: DCM/MeOH/NH4OH (gradient 0 to 90:10:1). The collected solid was suspended in EtOH, sonicated, and filtered. After further washing with EtOH/DCM, the filtered solid was then air-dried for 15 min, and then in vacuum oven overnight. The final product was collected as 70 mg (69%). LCMS E-S (M+H)=459.3 1H NMR (400 MHz, DMSO-d6) δ ppm 11.58 (s, 1 H) 9.00 (t, J=4.93 Hz, 1 H) 8.41 (s, 1 H) 8.36 (s, 1 H) 8.34 (s, 1 H) 8.24 (s, 1 H) 8.13 (s, 1 H) 8.06 (s, 1 H) 8.04 (s, 1 H) 7.51 (s, 1 H) 5.91 (s, 1 H) 5.37 (quin, J=6.69 Hz, 1 H) 4.42 (d, J=4.80 Hz, 2 H) 2.23 (s, 3 H) 2.13 (s, 3 H) 1.56 (s, 3 H) 1.55 (s, 3 H).

Workup

  1. custompreabsorbed onto silica gel
  2. customThe product was purified by silica gel chromatography (eluent
  3. customsonicated
  4. filtrationfiltered
  5. washAfter further washing with EtOH/DCM
  6. customthe filtered solid was then air-dried for 15 min
  7. customin vacuum oven overnight
  8. customThe final product was collected as 70 mg (69%)

Sources & evidence

ORD record
ord-7fdc87b561f54aafb7130d397a045765
Source dataset
uspto-grants-2015_07
Patent number
US09073924B2

Reaction notes

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