Sodium Hydroxide → HCID 67124654, compound

HRID 1522450Notes

Reaction equation

HRID 1522450 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([C:20]([O:22]CC)=[O:21])[C:7]3[C:12]([CH3:13])=[N:11][N:10]([C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)[C:8]=3[N:9]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([C:4]2[CH:5]=[C:6]([C:20]([OH:22])=[O:21])[C:7]3[C:12]([CH3:13])=[N:11][N:10]([C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)[C:8]=3[N:9]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68078899HCID 68078899, compound

Product 1

HCID 67124654HCID 67124654, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in the same manner as described for intermediate 46 using ethyl 6-cyclopropyl-1-(4-pyridinyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (240 mg, 0.796 mmol), sodium hydroxide (4 mL, 4.00 mmol), and ethanol (30 mL), wherein the stir time was 1 h. The final product was collected as 0.210 g (89%). LCMS E-S (M+H)=295.3.

Workup

  1. customThe final product was collected as 0.210 g (89%)

Sources & evidence

ORD record
ord-54c43a884d7240f585123617c7ed28af
Source dataset
uspto-grants-2015_07
Patent number
US09073924B2

Reaction notes

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