反应详情

温度

120 °C

7-Iodo-2H-pyrazolo[4,3-b]pyridine (300 mg, 1.224 mmol), 1-chloro-2-methylpropan-2-ol (133 mg, 1.224 mmol) and Cs2CO3 (399 mg, 1.224 mmol) were combined in DMF (5 mL). The mixture was heated at 120° C. for 30 minutes using a microwave. The reaction mixture was then purified by preparative HPLC using a Sunfire Prep 5 μm C18, 75×30 mm column eluting with a gradient of 05-25% acetonitrile (containing 0.035% TFA) in water (containing 0.05% TFA) using basic buffer to afford 1-(7-iodo-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropan-2-ol (170 mg, 0.536 mmol, 43.8% yield). MS [M+H] found 318.

1. customThe reaction mixture was then purified by preparative HPLC
2. washeluting with a gradient of 05-25% acetonitrile (containing 0.035% TFA) in water (containing 0.05% TFA)