反应详情

7-Iodo-1H-pyrazolo[4,3-b]pyridine (50 mg, 0.204 mmol), 2-(bromomethyl)tetrahydrofuran (33.7 mg, 0.204 mmol) and cesium carbonate (133 mg, 0.408 mmol) in DMF (1.0 mL) were heated in a microwave 80° C. for 15 minutes. The reaction was cooled, poured into water (10 mL) and extract with ethyl acetate (5 mL). The organics were dried over sodium sulfate, filtered and concentrated to provide 7-iodo-2-((tetrahydrofuran-2-yl)methyl)-2H-pyrazolo[4,3-b]pyridine (43 mg) which was used as is without further purification. MS [M+H] found 330.1.

1. temperatureThe reaction was cooled
2. extractionextract with ethyl acetate (5 mL)
3. dry with materialThe organics were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated