反应详情

温度

120 °C

7-Iodo-2H-pyrazolo[4,3-b]pyridine (200 mg, 0.816 mmol), 2-(3-bromopropoxy)tetrahydro-2H-pyran (182 mg, 0.816 mmol) and Cs2CO3 (532 mg, 1.633 mmol) were combined in DMF (5 mL) and the mixture was heated at 120° C. for 30 minutes in a microwave. The reaction mixture was then purified by preparative HPLC using a Sunfire Prep 5 μm C18, 75×30 mm column eluting with a gradient of 05-40% acetonitrile (containing 0.035% TFA) in water (containing 0.05% TFA) to give 7-iodo-2-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-2H-pyrazolo[4,3-b]pyridine and 7-iodo-1-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-1H-pyrazolo[4,3-b]pyridine. MS [M+H] found 388.0.

1. customThe reaction mixture was then purified by preparative HPLC
2. washeluting with a gradient of 05-40% acetonitrile (containing 0.035% TFA) in water (containing 0.05% TFA)