反应详情

温度

110 °C

To a solution of 7-chloro-6-fluoro-1H-pyrazolo[4,3-b]pyridine (300 mg, 1.749 mmol) in DMF (5 mL) was added Cs2CO3 (855 mg, 2.62 mmol) and 1-chloro-2-methylpropan-2-ol (209 mg, 1.924 mmol) and the mixture was heated at 110° C. for 2 hours. Water (20 mL) was then added and the mixture was extracted with EtOAc (2×50 mL). The combined organic layers were dried over Na2SO4, filtered, and evaporated to give 1-(7-chloro-6-fluoro-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropan-2-ol and 1-(7-chloro-6-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-2-methylpropan-2-ol which were used i without further purification. MS [M+H] found 244.2.

1. extractionthe mixture was extracted with EtOAc (2×50 mL)
2. dry with materialThe combined organic layers were dried over Na2SO4
3. filtrationfiltered
4. customevaporated