反应详情

温度

70 °C

N-(2-(2,5-Difluorophenyl)-5-methylpyridin-4-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine (100 mg, 0.296 mmol) was suspended in acetonitrile (3 mL). 2-Isocyanatopropane (29.1 μl, 0.296 mmol) was added and the reaction was stirred at 70° C. for 2 hours. The mixture was then cooled to give a solid which was collected by filtration to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.27 (6H, d, J=6.57 Hz) 2.38 (3H, s) 4.05-4.19 (1H, m) 7.26-7.45 (3H, m) 7.76 (1H, ddd, J=9.41, 6.13, 3.16 Hz) 7.93 (1H, s) 8.35-8.44 (1H, m) 8.54 (1H, s) 8.60 (1H, s) 8.82 (1H, d, J=8.34 Hz) 11.01 (1H, s). MS [M+H] found 423.5.

1. temperatureThe mixture was then cooled
2. customto give a solid which
3. filtrationwas collected by filtration