反应详情

温度

120 °C

7-Iodo-2H-pyrazolo[4,3-b]pyridine (357 mg, 1.457 mmol), 4-bromo-2-methylbutan-2-ol (243 mg, 1.457 mmol) and Cs2CO3 (475 mg, 1.457 mmol) were combined in DMF (5 mL) and heated in a microwave at 120° C. for 40 minutes. The reaction was then cooled, filtered, and concentrated to give a residue which was purified by silica chromatography eluted with a step gradient of EtOAc in hexanes to give 4-(7-iodo-1H-pyrazolo[4,3-b]pyridin-1-yl)-2-methylbutan-2-ol which was dried and used immediately.

1. temperatureThe reaction was then cooled
2. filtrationfiltered
3. concentrationconcentrated
4. customto give a residue which
5. customwas purified by silica chromatography
6. washeluted with a step gradient of EtOAc in hexanes