HRID1522719

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCC1(CCC)c2ccccc2-c2ccc(-c3ccc(C4=C(c5ccccc5)C(=O)C(c5ccccc5)=C4c4ccc(-c5ccc6c(c5)C(CCC)(CCC)c5ccccc5-6)cc4)cc3)cc21

HCID71065165

未命名化合物

HCID86084841

未命名化合物

PRODUCTS

生成物

结构：CCCC1(CCC)c2ccccc2-c2ccc(-c3ccc(-c4c(-c5ccccc5)cc(-c5ccc(-c6ccccn6)cc5)c(-c5ccccc5)c4-c4ccc(-c5ccc6c(c5)C(CCC)(CCC)c5ccccc5-6)cc4)cc3)cc21

HCID87747345

未命名化合物

收率 126.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID7583

Diphenyl oxide

C12H10O

CONDITIONS

反应条件

温度: 210 °C

PROCEDURE

实验过程

A solution of (10) (1.48 g, 1.67 mmol) and (3) (200 mg, 1.12 mmol) in diphenyl ether (3 mL) was deoxygenated and heated at 210° C. under argon for 3 hours. The crude product was purified by column chromatography over silica using dichloromethane: light petroleum (1:1) as the eluent. The main band was isolated and the solvent completely removed to give (11) (1.09 g, 95%).

WORKUP

后处理

customThe crude product was purified by column chromatography over silica
customThe main band was isolated
customthe solvent completely removed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1cbb7413a1634e608750197b27f11e99
来源数据集: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09078330B2
来源说明: uspto-grants-2015_07

反应 SMILES

C1(C2[C:8](=O)[C:9]([C:62]3[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=3)=[C:10]([C:37]3[CH:42]=[CH:41][C:40]([C:43]4[CH:55]=[CH:54][C:53]5[C:52]6[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=6)[C:46]([CH2:59][CH2:60][CH3:61])([CH2:56][CH2:57][CH3:58])[C:45]=5[CH:44]=4)=[CH:39][CH:38]=3)[C:11]=2[C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:30]=[CH:29][C:28]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[C:21]([CH2:34][CH2:35][CH3:36])([CH2:31][CH2:32][CH3:33])[C:20]=4[CH:19]=3)=[CH:14][CH:13]=2)C=CC=CC=1.[C:69]([C:71]1[CH:76]=[CH:75][C:74]([C:77]2[CH:82]=[CH:81][CH:80]=[CH:79][N:78]=2)=[CH:73][CH:72]=1)#[CH:70]>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:12]1([C:70]2[C:11]([C:12]3[CH:13]=[CH:14][C:15]([C:18]4[CH:30]=[CH:29][C:28]5[C:27]6[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=6)[C:21]([CH2:34][CH2:35][CH3:36])([CH2:31][CH2:32][CH3:33])[C:20]=5[CH:19]=4)=[CH:16][CH:17]=3)=[C:10]([C:37]3[CH:38]=[CH:39][C:40]([C:43]4[CH:55]=[CH:54][C:53]5[C:52]6[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=6)[C:46]([CH2:59][CH2:60][CH3:61])([CH2:56][CH2:57][CH3:58])[C:45]=5[CH:44]=4)=[CH:41][CH:42]=3)[C:9]([C:62]3[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=3)=[CH:8][C:69]=2[C:71]2[CH:76]=[CH:75][C:74]([C:77]3[CH:82]=[CH:81][CH:80]=[CH:79][N:78]=3)=[CH:73][CH:72]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1