Ethyl Acetate → 1401093-84-2

HRID 1522759Notes

Reaction equation

HRID 1522759 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH2:13][C:12]([CH3:19])([C:14]([O:16]CC)=[O:15])[O:11][N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+].C(OCC)(=O)C>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH2:13][C:12]([CH3:19])([C:14]([OH:16])=[O:15])[O:11][N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 68386558HCID 68386558, compound

Product 1

HCID 683870031401093-84-2

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.00 g (16.55 mmol) of ethyl 3-(3,5-dichlorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylate were dissolved in 50 ml of ethanol, and 24.82 ml of 1N NaOH were then added. After 1 h of stirring at RT, the solvent was removed, 100 ml of water were added and the aqueous phase was adjusted to pH 2 by addition of 2N HCl. The product formed was obtained by extraction with 100 ml of ethyl acetate, drying the organic phase over Na2SO4, filtration and concentration.

Workup

  1. customthe solvent was removed
  2. addition100 ml of water were added
  3. additionthe aqueous phase was adjusted to pH 2 by addition of 2N HCl
  4. customThe product formed
  5. customdrying the organic phase
  6. filtrationover Na2SO4, filtration and concentration

Sources & evidence

ORD record
ord-fc0131f8844f470b9810736ac1b88f45
Source dataset
uspto-grants-2015_07
Patent number
US09078442B2

Reaction notes

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