Sodium Hydroxide → HCID 68387020, compound

HRID 1522762Notes

Reaction equation

HRID 1522762 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH2:13][C:12]([CH2:19][OH:20])([C:14]([O:16]CC)=[O:15])[O:11][N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+]>CO.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH2:13][C:12]([CH2:19][OH:20])([C:14]([OH:16])=[O:15])[O:11][N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 68387183HCID 68387183, compound

Product 1

HCID 68387020HCID 68387020, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2.80 g (8.80 mmol) of ethyl 3-(3,5-dichlorophenyl)-5-(hydroxymethyl)-4,5-dihydro-1,2-oxazole-5-carboxylate were dissolved in 100 ml of methanol, and a solution of mg (11.4 mmol) of NaOH in 20 ml of water was added. After 18 h of stirring at RT, the solvents were removed under reduced pressure, water and methylene chloride were added and the organic phase was separated off. On acidification of the aqueous phase, the product separated off as a white precipitate, which was filtered off and dried.

Workup

  1. customthe solvents were removed under reduced pressure, water and methylene chloride
  2. additionwere added
  3. customthe organic phase was separated off
  4. customOn acidification of the aqueous phase, the product separated off as a white precipitate, which
  5. filtrationwas filtered off
  6. customdried

Sources & evidence

ORD record
ord-317a73f51e744c83a2baed170e807dd9
Source dataset
uspto-grants-2015_07
Patent number
US09078442B2

Reaction notes

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