Triethylamine → HCID 89444270, compound

HRID 1522776Notes

Reaction equation

HRID 1522776 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[C:9](/[C:27]([F:30])([F:29])[F:28])=[CH:10]\[C:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([NH:19][CH:20]3[CH2:23][S:22][CH2:21]3)=[O:18])=[C:15]([CH3:26])[CH:14]=2)=[O:12])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(=[S:33])C.C(N(CC)CC)C>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([SH:33])([C:27]([F:30])([F:29])[F:28])[CH2:10][C:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([NH:19][CH:20]3[CH2:23][S:22][CH2:21]3)=[O:18])=[C:15]([CH3:26])[CH:14]=2)=[O:12])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 67382514HCID 67382514, compoundHCID 178418634HCID 178418634, compound

Product 1

HCID 89444270HCID 89444270, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4-[(E)-3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide (500 mg) was added thioacetic acid (6 eq.) and triethylamine (4 μL). The solution was stirred under argon at room temperature for 41 hours. To this mixture was added a minimum of dichloromethane and then isolute. The suspension was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give:

Workup

  1. customThe suspension was evaporated under vacuo
  2. customThe residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate)
  3. customto give

Sources & evidence

ORD record
ord-ab57bc1f8b3c416e94ecafbdfe6cf106
Source dataset
uspto-grants-2015_07
Patent number
US09078444B2

Reaction notes

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