Acrylamide → HCID 66701704, compound

HRID 1522824Notes

Reaction equation

HRID 1522824 reaction equation
C([N:5]1[C:17]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[C:9](N)[C:8]=2[N:7]=[CH:6]1)C(C)C.C(OCCCC[CH2:28][CH:29]([CH3:31])[CH3:30])(=O)C=C.C([NH2:36])(=O)C=C.C(OCC)(=O)C>CO>[CH2:28]([N:7]1[C:8]2[C:17](=[C:16]([NH2:36])[CH:15]=[C:14]3[C:9]=2[N:10]=[CH:11][CH:12]=[CH:13]3)[N:5]=[CH:6]1)[CH:29]([CH3:31])[CH3:30]

Participants

6

Reactant 4

HCID 6579AcrylamideHCID 8857Ethyl AcetateHCID 57469Imiquimod2×HCID 165746Isooctyl acrylate

Product 1

HCID 66701704HCID 66701704, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the general method of Example 17 the formulations shown below are prepared. 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine or 1-(2-methylpropyl)-1Himidazo[4,5-c]quinolin-4-amine that had been ground with a mortar and pestle was used. The adhesive was the 93:7 isooctyl acrylate:acrylamide copolymer prepared in Preparative Method 1 above. The solvent was 90:10 ethyl acetate:methanol. All formulations in the following Table 8 were mixed at room temperature.

Workup

  1. custombelow are prepared
  2. additionAll formulations in the following Table 8 were mixed at room temperature

Sources & evidence

ORD record
ord-995b3f32d98544cd81f96f89c9bc40a2
Source dataset
uspto-grants-2015_07
Patent number
US09078889B2

Reaction notes

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