1,4-Dibromobutane → 1-Pyrrolidineethanol,beta-methyl-,(betaR)-(9CI)

HRID 1522845Notes

Reaction equation

HRID 1522845 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5]Br.[NH2:7][C@H:8]([CH3:11])[CH2:9][OH:10]>>[N:7]1([C@H:8]([CH3:11])[CH2:9][OH:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 80308(R)-(-)-2-Amino-1-propanol

Product 1

HCID 152030271-Pyrrolidineethanol,beta-methyl-,(betaR)-(9CI)

Procedure

The title compound was synthesized as described in Intermediate 9 using 1,4-dibromobutane and (R)-2-aminopropan-1-ol as starting materials. 1H NMR (CDCl3): δ 3.61 (m, 1H), 3.38 (m, 1H), 2.97 (br s, 1H), 2.72 (m, 1H), 2.60 (br s, 4H), 1.78 (br s, 4H), 1.06 (d, 3H).

Sources & evidence

ORD record
ord-f76d370ce6914fc7a98bf6b586ca4616
Source dataset
uspto-grants-2015_07
Patent number
US09078871B2

Reaction notes

Loading…