HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl {1-[2-oxo-2-(phenylamino)ethyl]piperidin-4-yl}carbamate | HCID 49817130 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(4-aminopiperidin-1-yl)-N-phenylacetamide | HCID 16227637 | — |
Reaction Steps
The product of stage 1 (0.28 g; 0.84 mmol) is stirred over night at r.t. with 10 mL 10% TFA in DCM. The solvent is removed to give 2-(4-amino-1-piperidyl)-N-phenyl-acetamide as a TFA salt (I.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09078909B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-ad9ae0ae150d49339f51a8a31ab3a21d |
| Source note | uspto-grants-2015_07 |