Trifluoroacetic acid → Trifluoroacetic acid

HRID 1522908Notes

Reaction equation

HRID 1522908 reaction equation
[NH:1]([C:8](=[O:24])[CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([NH:16]C(=O)OC(C)(C)C)[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>C(Cl)Cl>[NH2:16][CH:13]1[CH2:14][CH2:15][N:10]([CH2:9][C:8]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:24])[CH2:11][CH2:12]1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 49817130Tert-butyl {1-[2-oxo-2-(phenylamino)ethyl]piperidin-4-yl}carbamate

Product 2

HCID 6422Trifluoroacetic acidHCID 162276372-(4-aminopiperidin-1-yl)-N-phenylacetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of stage 1 (0.28 g; 0.84 mmol) is stirred over night at r.t. with 10 mL 10% TFA in DCM. The solvent is removed to give 2-(4-amino-1-piperidyl)-N-phenyl-acetamide as a TFA salt (I.1).

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-ad9ae0ae150d49339f51a8a31ab3a21d
Source dataset
uspto-grants-2015_07
Patent number
US09078909B2

Reaction notes

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