5-chloro-1H-indole-2,3-dione → 5-Chloro-1-(2-(piperidin-1-yl)ethyl)indoline-2,3-dione

HRID 1523018노트

반응식

HRID 1523018 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=C[CH:11]=2)[C:6](=O)[C:5]1=O)CC.[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[C:19]2=[O:26].BrCCN1CCCCC1>>[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([CH2:11][CH2:12][N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)[C:20](=[O:25])[C:19]2=[O:26]

참가 물질

4

반응물 3

HCID 872035-chloro-1H-indole-2,3-dioneHCID 4266111-(2-Bromoethyl)piperidineHCID 16450901-propyl-1H-indole-2,3-dione

생성물 1

HCID 80716865-Chloro-1-(2-(piperidin-1-yl)ethyl)indoline-2,3-dione

실험 절차

Was prepared in an analogous manner to 1-propylindoline-2,3-dione using commercially available 5-chloroisatin (purchased from Fisher Scientific) and 1-(2-bromoethyl)piperidine (purchased from Fisher Scientific). 1H-NMR δ 7.55 (m, 2H), 6.95 (d, 1H), 3.84 (t, 2H), 2.58 (t, 2H), 2.46 (bs, 4H), 1.54 (m, 4H), 1.43 (m, 2H).

출처 및 근거

ORD 기록
ord-738afd8c297b482d9b46f0c2e7edc803
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079853B2

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