1-Bromo-2-methylpropane → 5-Chloro-1-isobutylindoline-2,3-dione

HRID 1523025Notes

Reaction equation

HRID 1523025 reaction equation
C(N1[C:12]2[C:7](=[CH:8]C=CC=2)[C:6](=O)C1=O)CC.[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[C:19]2=[O:26].BrCC(C)C>>[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([CH2:6][CH:7]([CH3:12])[CH3:8])[C:20](=[O:25])[C:19]2=[O:26]

Participants

4

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 872035-chloro-1H-indole-2,3-dioneHCID 16450901-propyl-1H-indole-2,3-dione

Product 1

HCID 47368655-Chloro-1-isobutylindoline-2,3-dione

Procedure

Was made in an analogous fashion to 1-propylindoline-2,3-dione from commercially available 5-chloroisatin (purchased from Fisher Scientific) and 1-bromo-2-methylpropane (purchased from Fisher Scientific). 1H NMR δ 7.57 (m, 2H), 6.87 (d, 1H), 3.54 (d, 2H), 2.12 (m, 1H), 1.00 (d, 6H).

Sources & evidence

ORD record
ord-95f797f009024c599398db588d74297a
Source dataset
uspto-grants-2015_07
Patent number
US09079853B2

Reaction notes

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