1-Ethyl-5-methyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoate → 1-Isobutyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoate

HRID 1523091Notes

Reaction equation

HRID 1523091 reaction equation
C(OC1([CH2:23][C:24]2[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=2)C2C(=CC=C(C)C=2)N(CC)C1=O)(=O)C1C=CC=CC=1.[C:36]([O:44][CH:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[N:47]([CH2:54][CH:55]([CH3:57])[CH3:56])[C:46]1=[O:58])(=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[C:36]([O:44][C:45]1([CH2:23][C:24]2[CH:25]=[C:26]([O:34][CH3:35])[C:27]([O:32][CH3:33])=[C:28]([O:30][CH3:31])[CH:29]=2)[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[N:47]([CH2:54][CH:55]([CH3:56])[CH3:57])[C:46]1=[O:58])(=[O:43])[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 863006811-Ethyl-5-methyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoateHCID 904179011-Isobutyl-2-oxoindolin-3-yl benzoate

Product 1

HCID 863009681-Isobutyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoate

Procedure

This compound was made in an analogous fashion to 1-ethyl-5-methyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoate using 1-isobutyl-2-oxoindolin-3-yl benzoate. 1H-NMR δ 8.05 (d, 2H), 7.57 (dd, 1H), 7.43 (dd, 2H), 7.27 (m, 1H), 7.17 (d, 1H), 7.01 (dd, 1H), 6.73 (d, 1H), 6.17 (2H), 3.78 (s, 3H), 3.66 (s, 6H), 3.51 (m, 2H), 3.25 (m, 2H), 1.97 (m, 1H), 0.82 (dd, 6H). Calculated mass for C29H31NO6, 489.22. Observed 512.3 (M+Na).

Sources & evidence

ORD record
ord-3a0c1019ff754d5ba1370a86d632703d
Source dataset
uspto-grants-2015_07
Patent number
US09079853B2

Reaction notes

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