反应详情

To a solution of (S,Z)-tert-butyl 1-(4-bromophenyl)ethyl(3-(tert-butylthioimino)-3-phenylpropyl)carbamate (20 g, 0.037 mol) in THF (200 mL) was added (2-methylallyl)magnesium chloride (5.0 g, 0.044 mol) under nitrogen at −78° C. The mixture was stirred for 2 h. The reaction was quenched with satd aq NH4Cl. The organic phase was separated and concentrated to give crude tert-butyl(S)-1-(4-bromophenyl)ethyl(3-((R)-1,1-dimethylethylsulfinamido)-5-methyl-3-phenylhex-5-enyl)carbamate (6.5 g, 30%), which was purified by column chromatography.

1. customThe reaction was quenched with satd aq NH4Cl
2. customThe organic phase was separated
3. concentrationconcentrated