化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → tert-butyl (S)-1-(4-bromophenyl)ethyl(3-((R)-1,1-dimethylethylsulfinamido)-5-methyl-3-phenylhex-5-enyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | tert-butyl N-[(1S)-1-(4-bromophenyl)ethyl]-N-[(3Z)-3-tert-butylsulfanylimino-3-phenylpropyl]carbamate | HCID 87552777 | — |
| 反応物 | HCID 178448200 | HCID 178448200 | — |
| 生成物 | tert-butyl (S)-1-(4-bromophenyl)ethyl(3-((R)-1,1-dimethylethylsulfinamido)-5-methyl-3-phenylhex-5-enyl)carbamate | HCID 59627246 | 30% |
反応手順
To a solution of (S,Z)-tert-butyl 1-(4-bromophenyl)ethyl(3-(tert-butylthioimino)-3-phenylpropyl)carbamate (20 g, 0.037 mol) in THF (200 mL) was added (2-methylallyl)magnesium chloride (5.0 g, 0.044 mol) under nitrogen at −78° C. The mixture was stirred for 2 h. The reaction was quenched with satd aq NH4Cl. The organic phase was separated and concentrated to give crude tert-butyl(S)-1-(4-bromophenyl)ethyl(3-((R)-1,1-dimethylethylsulfinamido)-5-methyl-3-phenylhex-5-enyl)carbamate (6.5 g, 30%), which was purified by column chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09079861B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-58740204a41a43a1912e0937c18ba912 |
| 出典メモ | uspto-grants-2015_07 |