HCID 68779648, compound → HCID 59627200, compound

HRID 1523263Notes

Reaction equation

HRID 1523263 reaction equation
[CH2:1]([C@:4]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:9][CH2:8][N:7]([C@H:10]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH3:11])[C:6](=[O:18])[N:5]1[CH3:19])[CH:2]=[CH2:3].C([C@]1(C2C=CC=CC=2)CCN([C@H](C2CCCCC2)C)C(=[O:43])N1)C=C>>[CH:12]1([C@@H:10]([N:7]2[CH2:8][CH2:9][C@:4]([CH2:1][CH2:2][CH2:3][OH:43])([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:5]([CH3:19])[C:6]2=[O:18])[CH3:11])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.[CH2:1]([C@:4]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:9][CH2:8][N:7]([C@H:10]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH3:11])[C:6](=[O:18])[N:5]1[CH3:19])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 68779648HCID 68779648, compoundHCID 68781802HCID 68781802, compound

Product 2

HCID 59627200HCID 59627200, compoundHCID 68781802HCID 68781802, compound

Procedure

The title compound was prepared from (R)-4-allyl-1-((S)-1-cyclohexylethyl)-3-methyl-4-phenyltetrahydropyrimidin-2(1H)-one following a procedure analogous to that described in Example 7. (R)-4-allyl-1-((S)-1-cyclohexylethyl)-3-methyl-4-phenyltetrahydropyrimidin-2(1H)-one was prepared from (R)-4-allyl-1-((S)-1-cyclohexylethyl)-4-phenyltetrahydropyrimidin-2(1H)-one following a procedure analogous to that described in Example 3. LC-MS Method 2 tR=1.408 min, m/z=359.1; 1H NMR (CDCl3) δ=1.06 (m, 3H), 1.10 (m, 3H), 1.23 (m, 3H), 1.52 (m, 7H), 1.75 (m, 2H), 1.98 (m, 1H), 2.15 (m, 2H), 2.60 (m, 1H), 2.87 (m, 3H), 3.70 (m, 2H), 4.22 (m, 11-1), 7.17 (m, 4H), 7.28 (m, 2H).

Sources & evidence

ORD record
ord-3d63c79f3a3641d09c1d031aa7da20a3
Source dataset
uspto-grants-2015_07
Patent number
US09079861B2

Reaction notes

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