Hydrochloric Acid → HCID 178507214, compound

Participants

Reaction Steps

To tert-butyl [4-({4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}methyl)tetrahydro-2H-pyran-4-yl]carbamate (Preparation 4, 0.166 g, 0.376 mmol) was added 4M hydrogen chloride in 1,4-dioxane (3 mL) and the reaction left to stir at room temperature for 18 hours before concentrating in vacuo. The residue was purified by preparative HPLC conditions (A-HPLC) to afford the title compound.

Provenance & Evidence