Hydrochloric Acid → HCID 178507214, compound

HRID 1523276Notes

Reaction equation

HRID 1523276 reaction equation
[F:1][C:2]([F:31])([F:30])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:15][C:16]3([NH:22]C(=O)OC(C)(C)C)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[NH:13][CH:14]=2)=[CH:6][CH:5]=1.Cl>O1CCOCC1>[F:31][C:2]([F:1])([F:30])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:15][C:16]3([NH2:22])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[NH:13][CH:14]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452627HCID 178452627, compound

Product 1

HCID 178507214HCID 178507214, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl [4-({4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}methyl)tetrahydro-2H-pyran-4-yl]carbamate (Preparation 4, 0.166 g, 0.376 mmol) was added 4M hydrogen chloride in 1,4-dioxane (3 mL) and the reaction left to stir at room temperature for 18 hours before concentrating in vacuo. The residue was purified by preparative HPLC conditions (A-HPLC) to afford the title compound.

Workup

  1. waitthe reaction left
  2. concentrationbefore concentrating in vacuo
  3. customThe residue was purified by preparative HPLC conditions (A-HPLC)

Sources & evidence

ORD record
ord-23b93ced25c6427f95d9f47076c4c4bf
Source dataset
uspto-grants-2015_07
Patent number
US09079878B2

Reaction notes

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