Hydrochloric Acid → SUVN-G3031 hydrochloride

HRID 1523405Notes

Reaction equation

HRID 1523405 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:27])[CH2:20][N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:28]>C(OCC)C.CO>[ClH:28].[ClH:28].[CH:1]1([N:5]2[CH2:6][CH2:7][CH:8]([O:11][C:12]3[CH:13]=[CH:14][C:15]([NH:18][C:19](=[O:27])[CH2:20][N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)=[CH:16][CH:17]=3)[CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 60151477SUVN-G3031

Product 1

HCID 60151476SUVN-G3031 hydrochlorideYield 83.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirred solution of N-[4-(1-Cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide (70 g, 0.187 moles) in diethyl ether (2.3 L) and methanol (350 mL) was treated with 31.5% w/v methanolic hydrochloric acid (54.36 mL, 0.469 moles). The reaction mass was further stirred 2-3 hours at room temperature. The solvent was decanted and the resulting solid mass was washed with ether (3×250 mL) and dried under reduced pressure to obtain title compound 70 g (Yield: 83.9%).

Workup

  1. customThe solvent was decanted
  2. washthe resulting solid mass was washed with ether (3×250 mL)
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-488c272d355045f7839a18ce94b4efe1
Source dataset
uspto-grants-2015_07
Patent number
US09079888B2

Reaction notes

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