Hydrochloric Acid → HCID 60196777, compound

HRID 1523407Notes

Reaction equation

HRID 1523407 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][CH2:19][C:20]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[O:21])=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:28]>C(OCC)C>[ClH:28].[CH:1]1([N:5]2[CH2:6][CH2:7][CH:8]([O:11][C:12]3[CH:13]=[CH:14][C:15]([NH:18][CH2:19][C:20]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[O:21])=[CH:16][CH:17]=3)[CH2:9][CH2:10]2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 60196778HCID 60196778, compound

Product 1

HCID 60196777HCID 60196777, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a stirred solution of 2-[4-(1-Cyclobutyl piperidin-4-yloxy)phenylamino]-1-(morpholin-4-yl)ethanone (0.3 g, 0.804 mmoles) in diethyl ether (20 mL) was treated with 15% methanolic hydrochloride (0.23 mL, 0.965 mmoles). The reaction mass was stirred further for 1 hour at room temperature. The solvent was decanted, the resulting solids were washed with ether (2×10 mL) and dried under reduced pressure to obtain title compound 0.28 g (Yield: 85%).

Workup

  1. customThe solvent was decanted
  2. washthe resulting solids were washed with ether (2×10 mL)
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-6794c3f118fb4eabbb370b3f9337108f
Source dataset
uspto-grants-2015_07
Patent number
US09079888B2

Reaction notes

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