Hydrochloric Acid → HCID 60196779, compound

HRID 1523410Notes

Reaction equation

HRID 1523410 reaction equation
[ClH:1].[CH:2]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:28])[CH2:21][N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[C:15]([F:29])[CH:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1>C(OCC)C>[ClH:1].[ClH:1].[CH:2]1([N:6]2[CH2:7][CH2:8][CH:9]([O:12][C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:28])[CH2:21][N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[C:15]([F:29])[CH:14]=3)[CH2:10][CH2:11]2)[CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 60196780HCID 60196780, compound

Product 1

HCID 60196779HCID 60196779, compoundYield 86.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Methanolic hydrochloride (2.08 ml, 0.009 moles, 15% w/v) was added to a stirred solution of N-[4-(1-Cyclobutyl piperidin-4-yloxy)-2-fluoro phenyl]-2-(morpholin-4-yl) acetamide (1.52 g, 0.004 moles) in diethyl ether (5 vol) and the reaction mass was further stirred for 2-3 hours at room temperature. The solvent was decanted; the resulting solids were washed with ether (2×10 mL) and dried under reduced pressure to obtain the title compound 1.6 g (Yield: 86.2%).

Workup

  1. customThe solvent was decanted
  2. washthe resulting solids were washed with ether (2×10 mL)
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-2ce4aedfe64c435ab90ec3166804b963
Source dataset
uspto-grants-2015_07
Patent number
US09079888B2

Reaction notes

Loading…