Lithium Bromide → 2-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]isoindole-1,3-dione

HRID 1523703Notes

Reaction equation

[O:1]1[CH2:3][C@@H:2]1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].[N:16]([C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][C:26]2=[O:31])=[CH:21][CH:20]=1)=[C:17]=[O:18].[Br-].[Li+]>C1(C)C=CC=CC=1>[O:18]=[C:17]1[N:16]([C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][C:26]3=[O:31])=[CH:21][CH:20]=2)[CH2:3][C@H:2]([CH2:4][N:5]2[C:13](=[O:14])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]2=[O:15])[O:1]1

Participants

Conditions

Temperature: 100 °C

Procedure

(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (3.51 g, 17.29 mmol, 1.0 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in toluene (70 mL) respectively and heated to 100° C. Then lithium bromide (0.15 g, 1.74 mmol) was added, and the mixture was reacted for 4 h. White solid was obtained by filtration (6.50 g, yield: 89.28%).

Workup

customthe mixture was reacted for 4 h
customWhite solid was obtained by filtration (6.50 g, yield: 89.28%)

Sources & evidence

ORD record: ord-07063ba578bd4b0f8d45f251783dd201
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09079892B2

Reaction notes

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