反应详情

To a stirred solution of 5-chloro-7-{5-[1-(tetrahydro pyran-4-yl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-2,3-dihydro benzofuran-4-ylamine (20.4 mg, 0.05 mmol) in ethanol (2 mL), oxalic acid (6.0 mg, 0.05 mmol) was added. After stirring at room temperature for 1 hour the reaction was further diluted with 2-propanol and refluxed for 2 hour; The volatiles were removed under reduced pressure and the crude product obtained was triturated with ether, dried under vacuum to obtain 5-chloro-7-{5-[1-(tetrahydro pyran-4-yl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-2,3-dihydro benzofuran-4-ylamine oxalate salt (22.5 mg).

1. temperaturerefluxed for 2 hour
2. customThe volatiles were removed under reduced pressure
3. customthe crude product obtained
4. customwas triturated with ether
5. customdried under vacuum