HCID 90327746, compound → HCID 90314014, compound

HRID 1523756Notes

Reaction equation

HRID 1523756 reaction equation
[Br:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][S:5]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]1)(=[O:7])=[O:6]>CO.Cl>[Br:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][S:5]([N:8]1[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]1)(=[O:6])=[O:7]

Participants

3

Reactant 1

HCID 90327746HCID 90327746, compound

Product 1

HCID 90314014HCID 90314014, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A mixture of tert-butyl (1-((2-bromobenzyl)sulfonyl)piperidin-4-yl)carbamate (500 mg, 1.15 mmol) in HCl methanol (6 N, 20 mL) was stirred at rt for 24 hours, and then concentrated to dryness to give 1-(2-bromobenzylsulfonyl)piperidin-4-amine.HCl (400 mg, 94%), which was directly used for next step without any further purification. MS (ESI): mass calcd. for C14H19BrN2O3S, 332.02; m/z found, 332.9 [M+H]+.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-67608ca0e8a643728a82991befd03b42
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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