HCID 90327746, compound → HCID 90314014, compound

Participants

Reaction Steps

A mixture of tert-butyl (1-((2-bromobenzyl)sulfonyl)piperidin-4-yl)carbamate (500 mg, 1.15 mmol) in HCl methanol (6 N, 20 mL) was stirred at rt for 24 hours, and then concentrated to dryness to give 1-(2-bromobenzylsulfonyl)piperidin-4-amine.HCl (400 mg, 94%), which was directly used for next step without any further purification. MS (ESI): mass calcd. for C14H19BrN2O3S, 332.02; m/z found, 332.9 [M+H]+.

Provenance & Evidence